Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns

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Figure 5.
Figure 5.

Relationship between DNA methylation, histone modification, chromatin proteins, and nucleosome positioning. (A) m5CpG and CpG densities, ChIP-seq scores, and DNase hypersensitivity scores are plotted relative to promoter TSSs for 16,181 RefSeq genes. (B) CpG methylation plotted as a function of histone modifications, chromatin factors, and RNA polymerase II occupancy. Note the strong negative relationship between DNA methylation and density of H3K4me3 and H2A.Z and the lack of a strong association between DNA methylation status and most histone modifications.

This Article

  1. Published in Advance May 20, 2010, doi: 10.1101/gr.101535.109 Genome Res. 20: 972-980

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