Mutational profile across 23 gypsy element insertions. The C. immitis RS genome contains 23 full-length copies of a particular family of gypsy elements, 19 of which have substantial levels of modification at CpG residues. Analyzing only those locations that contain CpG in any of the 23 elements, this figure illustrates the two kinds of modifications seen. The green and red data points illustrate the almost complete modification of CpG to CpA (or TpG if on the other strand). There are no elements with intermediate levels of CpG content. The yellow data points illustrate the modification of CpA dinucleotides to a TpA occurring at a much more gradual pace, perhaps by a distinct process from that which makes the initial, high-efficiency CpG modifications.
