Phylogram of arthropod and Branchiostoma E(spl)-C-related bHLH proteins. Bayesian phylogeny of bHLH proteins from sequenced Arthropod genomes rooted with Brachiostoma HES genes. Posterior probabilities are shown at nodes. Names of proteins and their respective species are shown in Figure 4 and in Supplemental Table 1. The phylogenetic analysis recovers six well-supported clades, a clade of Brachiostoma proteins, a clade of proteins that cluster with Drosophila CWO, a clade that contains both Hairy and Deadpan proteins, a clade clustering with Drosophila SIDE, and a final, poorly resolved clade containing proteins clustering with Drosophila E(spl)-C bHLH and HER. Drosophila HER is circled in red. Ixodes ISCW016537 and ISCW016540, apparent tandem duplications of a Deadpan-like protein, are circled in blue.
