Figure 4.
CARs are conserved across species. Distribution of the proportion of CAR regions that overlap with conserved phastCons elements (44wayPlacental, UCSC Genome Browser) across intronic (A) and intergenic (C) CARs. Distributions of overlap with phastCons elements for the randomized intronic (B) and intergenic (D) control sets from matching genomic locations. (E) Distribution of overlap to randomly selected 1-kb exonic regions. Both intronic and intergenic CAR regions are significantly more conserved than control regions (P = 2.1 × 10−12, P = 7.1 × 10−4, respectively).
