Figure 5.
Elements of transcription regulation. Ubiquitous promoters have high CG content and are regulated by a few TFs. Tissue-specific promoters tend to have low CG content and a TATA box and are regulated by many TFs. Promoter activity of the proximal promoter is primarily determined by sequence content, while endogenous gene expression is additionally influenced by chromatin, DNA methylation, and long-range elements. Note that the molecules in this figure are not drawn to scale.
