The mutational spectrum of non-CpG DNA varies with CpG content

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Percent total transitions, transversions, and transition/transversion ratio as a function of CpG content. Mutations undergone by the chimpanzee and human members of the ortholog pairs from each L1Pa family were classified as transitions or transversions as described in the Methods (Determination of the Mutational Spectrum) and plotted as a function of the % CpG content. The transition/transversion ratio for each L1Pa family and its corresponding CpG content are plotted in the right most panel.

This Article

  1. Genome Res. 20: 875-882

Preprint Server