Figure 2.
Genome-wide mapping of DNA methylation in MCF-7 breast cancer cells. MCF-7 cells were stimulated with E2 for 4 h and then subjected to MeDIP-chip. Combined with Pol II ChIP-seq data of MDECs and MCF-7 cells, 11 hypermethylated zones, as indicated by the blue open rectangles, are potential regions susceptible to estrogen-mediated epigenetic silencing.
