Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

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Figure 3.
Figure 3.

H3K27me3 profiles suggest a central role in beta-cell identity. (A) Beta-cell H3K27me3 preferentially targets genes that promote alternate developmental fates. (B) H3K27me3 is also enriched in genes whose expression is known to be deleterious for mature beta-cells.

This Article

  1. Published in Advance April 15, 2010, doi: 10.1101/gr.101709.109 Genome Res. 20: 722-732

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