Figure 5.
Correlation of estrogen receptor and cohesin binding events with estrogen gene regulation. (A) Estrogen binding alone enriches for functional targets. The genes that have an ER binding event are 1.4 times more likely to have changed their gene expression than expected by random chance (Fisher's exact test, P-value = 10−18). (B) Genes bound by both ER and cohesin (but not CTCF) are 2.2 times more likely to have altered gene expression upon estrogen treatment than by random chance, further enriching functional targets (Fisher's exact test, P-value = 10−41).
