Figure 4.
GC content, SNP density, and human–chimp divergence profiles of 5194 E2F1 HCTs. The GC content and the divergence from chimp increase, while the SNP density decreases sharply in HCTs as compared to flanking regions, which show values similar to the genome average. The increased GC content at the beginning and end of the HCT is due to the first and last E2F1 TFBSs that define the HCT, whereas the position of the other TFBSs is variable. All values were computed by avoiding coding and repetitive sequences.
