Figure 7.
Transcriptional regulation of target genes in TS cells. (A) Model for integration of TCFAP2C, SMARCA4, and EOMES with core transcriptional machinery in TS cells. Colored circles represent the investigated factors, and arrows represent direction of transcriptional regulation. (B) Extended transcriptional network in TS cells integrating the investigated five factors with downstream target genes. Open circles represent target genes. (C) Transcriptional regulation within the five factors, including autoregulation of TCFAP2C and EOMES. (D) Summary of genes coexpressed or uniquely expressed in TS cells, ES cells, and their differentiated progeny.
