Increase in human and mouse non-CpG divergence and diversity during the S phase. (A) The human global substitution rate (blue) and diversity (Levy et al. 2007) (red) as a function of replication timing. The relative increase in the human global rate as a function of timing (28%) is the same as the relative increase in diversity (29%). (B) (Blue) Mouse–rat divergence; (red) mouse diversity; the relative increase of mouse divergence (16%) is smaller than that of diversity (30%). This likely results from substitution saturation due to long evolutionary time since the mouse/rat divergence. Correlation coefficients (Pearson): human diversity and timing (R = 0.23, P < 10−16); mouse diversity and timing (R = 0.21, P < 10−16). All rates are determined in 100-kb windows.
