Figure 1.
Gene fusions in melanoma. (A) RB1-ITM2B gene fusion in short-term culture M990802. ITM2B is transcribed immediately upstream of RB1 on chromosome 13, yet in M990802, a fusion transcript beginning with the 5′ end of RB1 and ending with the 3′ end of ITM2B is implicated by 14 distinct read pairs and two individual fusion-spanning reads. (B) RECK-ALX3 gene fusion in short-term culture M000921. Two alternate transcripts are observed in the RNA-seq data: One joining exon 13 of RECK to exon 3 of ALX3, and one joining exon 14 of RECK to exon 3 of ALX3. (C) Spatial distribution of sequence reads for RECK and ALX3 are consistent with a fusion transcript containing the 5′ end of RECK and the 3′ end of ALX3.
