Genome-wide discovery of human heart enhancers

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Figure 4.
Figure 4.

Experimental validation of predicted heart enhancers. (A) Four predicted heart enhancers driving expression of the reporter genes GFP in transgenic zebrafish (first column) and lacZ in transgenic mouse embryos (second column). (Red arrows) Expression of the reporter genes in the heart. (Third column) Reporter expression in dissected hearts for each of the constructs shown. Coordinates are hg18. (B) Positive and negative predicted heart enhancers identified in zebrafish transgenics. (Top image) Transgenic zebrafish displaying GFP expression in the heart driven by a predicted heart enhancer (positive). (Bottom image) Another predicted heart enhancer that did not drive reporter gene expression in the heart (negative).

This Article

  1. Published in Advance January 14, 2010, doi: 10.1101/gr.098657.109 Genome Res. 20: 381-392

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