Figure 5.
Age-related changes in mRNA expression in large intestine. Expression was measured for four genes showing age-related hypermethylation (Gpr37, Hoxa11, Pcdh10, and Prdm5), one showing age-related hypomethylation (P2rx7) and two (Tmp2 and Cpe) showing unchanged methylation with age. The expression data for each gene was Z-score transformed, and we averaged values for hyper/hypo/unchanged methylation. Black and gray solid bars represent the expression level of hypermethylated and hypomethylated genes with age. (Y) Young tissues; (O) old tissues. Bars represent standard error. *P < 0.05
