Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomes

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

Variation and evolutionary constraint in three personal genomes. (A) Coverage of the human genome by mammalian alignment depth (solid line) and level of constraint (broken line). (B) Ratio of the number of SNVs observed in the three individual genomes at sites within the given RS score range to the number expected, given the distribution of RS scores across the human genome.

This Article

  1. Published in Advance January 12, 2010, doi: 10.1101/gr.102210.109 Genome Res. 20: 301-310

Preprint Server



Current Issue

  1. January 2026, 36 (1)
  1. Current Issue
  1. Alert me to new issues of Genome Research