A high-resolution association mapping panel for the dissection of complex traits in mice

Detection of associations for plasma lipids in HMDP strains coincide with a corresponding QTL in C57BL/6 × C3H/HeJ F₂ crosses. Six to ten mice of each strain were examined for the given phenotypes as described in Methods. (A) Plasma HDL levels in the HMDP. (B) GWAS for plasma high-density lipoprotein cholesterol. (C) Comparison of association results with linkage results on chromosome 1. Linkage data from a previously reported F₂ cross between C3H/HeJ and C57BL/6J (Wang et al. 2007). These results demonstrate the power of the HMDP to detect associations for QTL observed in the F₂ cross, and also highlight the vastly improved resolution of association testing with the HMDP.