Cross-mapping and the identification of editing sites in mature microRNAs in high-throughput sequencing libraries

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Figure 5.
Figure 5.

Comparison of miRNA expression before and after cross-mapping correction. This scatter plot shows the expression of miRNAs before and after correcting for cross-mapping. With a Spearman correlation coefficient of 0.99, the cross-mapping correction has a minor effect on the estimated expression of most miRNAs. However, for 14 miRNAs the relative difference between the estimated expression with and without the cross-mapping correction was larger than 50%. These miRNAs are circled and shown together with their short RNA counts before and after the cross-mapping correction.

This Article

  1. Published in Advance January 5, 2010, doi: 10.1101/gr.095273.109 Genome Res. 20: 257-264

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