Figure 4.
ORC localizes to open dynamic chromatin. (A) ORC binding sites are enriched for the histone variant H3.3. The average enrichment of H3.3 was plotted relative to the position of all ORC binding sites. The ORC binding sites were classified as either proximal or distal to annotated transcription start sites. Proximal ORC binding sites directly overlap with annotated promoters. (B) ORC binding sites are depleted for nucleosomes. The average depletion of nucleosomes was plotted relative to the position of promoter-proximal or -distal ORC binding sites.
