Figure 3.
ORC associates with promoters of active genes. (A) Venn diagram depicting the overlap between ORC-associated sequences and annotated transcription start sites. (B) ORC localizes to the promoter regions of actively transcribed genes. The mRNA expression levels for approximately 15,000 Drosophila transcripts were determined by Affymetrix expression analysis. The mRNA expression levels for each gene were binned into five equal quintiles (Supplemental Fig. 2). The average ORC enrichment for each quintile of expression is plotted relative to the transcription start site.
