Evaluation of affinity-based genome-wide DNA methylation data: Effects of CpG density, amplification bias, and copy number variation

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Figure 7.
Figure 7.

Effects of copy number changes on differential methylation detection. (A) Differential methylation Z-score for between LNCaP and PrEC cells, using MBD-SF-seq, for human chromosome 13. (B) Smoothed Affymetrix SNP 6.0 array data showing corresponding changes in copy number. (C) Genome-wide distributions of Z-scores, stratified by the change-in-copy-number status of the corresponding regions.

This Article

  1. Published in Advance November 2, 2010, doi: 10.1101/gr.110601.110 Genome Res. 20: 1719-1729

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