Coevolution within a transcriptional network by compensatory trans and cis mutations

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Figure 2.
Figure 2.

Evolution of the yAP-1 TFs. (A) CgAp1 possesses a lysine at residue 12 (CgAp1.46), while most other species possess an arginine. (B) Sequencing of CgAP1 in two unrelated isolates shows complete identity to the Cg reference genome. (C) Phylogenetic clustering of all Sc and Cg AP-1 DNA-binding domains reveals that CgAp1 and ScYap1 co-cluster. Internal branch point numbers refer to the Bayesian posterior probability, a measure of confidence (Drummond and Rambaut 2007).

This Article

  1. Genome Res. 20: 1672-1678

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