A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

Distribution of crossover breakpoints within the NOD.B6Idd11D congenic interval. Seven-hundred-twenty-three F2 pups (1446 meiosis events) were derived from intercrossing NOD.B6Idd11D F1 mice and were genotyped for markers within the NOD.B6Idd11D congenic interval. The crossover activity was calculated by dividing the frequency of crossovers in each interval by its length. For example, five pups had a recombination between D4Wehi5 and D4Wehi6, giving rise to a genetic distance of 0.345 cM across this 6859-bp interval, which is ∼50 cM Mb-1. Bars, crossover frequency in cM/Mb in each interval. Above each bar, the number of crossovers observed in that marker interval is shown. The dashed line indicates the average crossover activity for the mouse genome: ∼0.5cM/Mb (Shiroishi et al. 1995). Genetic markers are indicated by ticks above the plot. The inset displays an enlarged view of the interval between D4Wehi2 and D4Wehi17.

This Article

  1. Published in Advance November 4, 2010, doi: 10.1101/gr.101881.109 Genome Res. 20: 1629-1638

Preprint Server



Current Issue

  1. February 2026, 36 (2)
  1. Current Issue
  1. Alert me to new issues of Genome Research