Inferring tumor progression from genomic heterogeneity

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Figure 1.
Figure 1.

Sector-Ploidy-Profiling (SPP) approach. The SPP approach separates tumor subpopulations by macro-dissection and cell sorting by ploidy. (A) Macro-dissection of tumor sectors. (B) Sorting of DAPI-stained nuclei using FACS by differences in total genomic DNA content. (C) Profiling of chromosome breakpoints across the genome by ROMA CGH. (D) Calculation of neighbor-joining trees using copy number profiles. (E) Coalescence of highly similar copy number profiles. (F) Topography of subpopulations in the tumor. Tumor sectors S7–S12 are colored according to the adjacent subpopulations in S1–S6.

This Article

  1. Published in Advance November 10, 2009, doi: 10.1101/gr.099622.109 Genome Res. 20: 68-80

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