An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity

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Figure 3.
Figure 3.

Haplotypes within Bhmt2 and G6pc for 16 inbred mouse strains. Each row represents one SNP and the color of each box represents the allele. A blue box denotes the common (or major) allele, while a yellow box is the less common (or minor) allele; a gray box indicates the allele is unknown. Groups of SNPs within Bhmt2 (N = 22) and G6pc (N = 11) form three distinct haplotypes for each gene across the 16 strains analyzed. Neither gene has a unique haplotype in the SJL/J strain, which is uniquely resistant to acetaminophen-induced liver injury.

This Article

  1. Genome Res. 20: 28-35

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