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Cover Suspended over a liver and sectioned liver tissue background are the structural formulas for acetaminophen (right) and S-methylmethionine (SMM) (over lobe filled with capsules). SMM, a Chinese herbal medicine and dietary metabolite abundant in all flowering plants, is the substrate of BHMT2, an enzyme identified to confer protection against acetaminophen-induced liver injury in vivo. (Cover illustration by Myriam Kirkman-Oh, KO Studios, http://www.kostudios.com. [For details, see Liu et al., pp. 28–35.])

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