Instrumenting the health care enterprise for discovery research in the genomic era

The cost of sample acquisition, phenotyping and genotyping in dollars used for the models illustrated in Fig. 5. The three costs for sample acquisition costs are the low and high costs using i2b2 per sample versus the current cost (denoted LS, HS, CS). The current cost for reviewing one record to phenotype a patient (CP1) or, more typically, five records reviewed per study patient identified are denoted CP1 and CP2 and i2b2 phenotyping as iP. Current cost genome-scale genotyping versus lower cost genotyping within three years are denoted CG and LG.

^aData from Asthma Driving Biology Project (DBP).

^bSee Figure 2.