Projected accrual rates. Estimates are based on the number of patients previously seen at least once during the 36 mo before June 30, 2006 for whom at least one patient visit during which chemistry or hematology samples were obtained was then recorded in the following 12 mo. Each patient was only counted once, even if they had more than one visit in the 12-mo period. Also, unlike Figure 2, accrual rates per week rather than cumulative accrual are shown. There are some common features in the accrual trajectories for most of the diseases because of the shared exposure to the effects of holidays and seasonality on hospital visits. (A) Accrual for common diseases: (MDD) major depressive disorder; (RA) rheumatoid arthritis (all individuals and not just those who met driving biological projects criteria); asthma (also all individuals). (B) Accrual for less prevalent diagnoses: Huntington disease and autism spectrum disorder (ASD) (including Asperger syndrome).
