Identification of rare cancer driver mutations by network reconstruction

Entries include the number of mutations mapping to each module, the significance of mutation enrichment in each module, and the rank of the module out of the total number of modules containing mutations in each mutation category. Bold and underlined entries are significant, bold-only entries are marginally significant and high ranked, italicized entries are suggestive by rank and significance. Breast cancer modules 16 and 33 are closely related by clustering and overlap significantly with colon module 6. Breast cancer modules 26 and 27 are closely related by clustering. Threshold for significance for mutations mapped to their corresponding tissue is 1.98 × 10⁻⁴ and to other tissues is 9.92 × 10⁻⁵. Threshold for significance for CAN mutations mapped to their corresponding tissue is 0.006 and to other tissues is 0.003.

NA, Not available.