Alison H. Harrill; Paul B. Watkins; Stephen Su; Pamela K. Ross; David E. Harbourt; Ioannis M. Stylianou; Gary A. Boorman; Mark W. Russo; Richard S. Sackler; Stephen C. Harris; Philip C. Smith; Raymond Tennant; Molly Bogue; Kenneth Paigen; Christopher Harris; Tanupriya Contractor; Timothy Wiltshire; Ivan Rusyn; David W. Threadgill

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

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Figure 5.

Polymorphisms in CD44 (A–C) and CAPN10 (D–F) associated with susceptibility to acetaminophen-induced liver injury in humans. Data from UNC (A,D), Purdue Pharma (B,C) and a combined cohort (C,F) are shown. Average mean (±SE) serum ALT per genotype is plotted for each matching study day.