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CoverGenome Research welcomes the era of personal genomes with a special issue on Personal Genomes and Variation, wherein insights gained from whole-genome and targeted resequencing, cutting-edge methods to characterize variation within and across populations, and novel resources in genomic medicine hold the promise of Personal Genomics—to improve prevention, diagnosis, and treatment of disease as well as to enhance our knowledge of our ancestry. (Illustration by Victor O. Leshyk, www.victorleshyk.com.)

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