Figure 3.
Conservation of the genomic context surrounding GPR173 and KDM5C indicates that their chicken homologs are paralogs and not orthologs. The gene arrangements surrounding the GPR173 and KDM5C paralogs are well conserved: (A) GPR27 (light red), (B) GPR85 (dark red), (C) KDM5B (orange), and (D) KDM5A (yellow). (E) Schematic representation of the gene arrangements of paralogous and orthologous regions to Xp11 stratum 2 genes across the vertebrates. Genes from the proposed Xp11 stratum 2a region (light blue) and the human Xq22 region (dark blue) containing GLA, DRP2, and WDR44 is indicated.
