Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to up-regulate gene expression

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Figure 4.
Figure 4.

Gene expression around Hoxb and Hoxd during ES cell differentiation. (A) Signal intensities of cDNAs from undifferentiated ES cells (UN, white columns) or from cells differentiated for 3 d (D3, black columns) monitored using a cDNA microarray (GEO accession GSE15166). Results for pluripotency (Oct4, Sox2, Nanog) and housekeeping genes (Rrm2, Hprt1) (left), and the Hoxb (middle) or Hoxd (right) genomic regions are shown. (B) As in A, but showing the log2 ratio of D3/UN cDNA on a cDNA microarray (light hatched columns) or a Hoxb/Hoxd tiling microarray (dark hatched columns). Data are the mean of three independent experiments including a dye swap.

This Article

  1. Published in Advance April 23, 2009, doi: 10.1101/gr.089045.108 Genome Res. 19: 1184-1194

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