Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to up-regulate gene expression

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Figure 1.
Figure 1.

Comparative genomic structure of Hoxb and Hoxd. Map of the 2 Mb genomic regions surrounding Hoxb on MMU11 (A) and surrounding Hoxd on MMU2 (B) showing the position of genes, the level of conservation between the murine locus and other vertebrates, and the position of BACs and fosmids used as probes in this study (Supplemental Table S1). The Hoxb and Hoxd loci are boxed in black. The gray box locates a region of noncoding sequence conservation that includes the global control region (GCR). Data and map positions (bp) are taken from the August 2005 NCBI Build 35 of the mouse genome (http://genome.ucsc.edu/cgi-bin/hgGateway) and from Ensembl v37, February 2006 (http://www.ensembl.org/Mus_musculus/index.html).

This Article

  1. Genome Res. 19: 1184-1194

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