The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression

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Figure 4.
Figure 4.

SMAD7 expression in 36 rectal adenomas and 43 carcinomas. Vertical axis present normalized relative SMAD7 gene expression (Log2-scale). Expression of SMAD7 was significantly lower in carcinomas than adenomas, irrespective of 18q21 copy-number status. (Difference of expression between tumor groups: 1 vs. 2, P = 0.524; 3 vs. 4, P = 0.34; 1 vs. 3, P = 0.13; 2 vs. 4, P = 4.0 × 10−4; 1,3 vs. 2,4, P = 0.06; 1,2 vs. 3,4, P = 5.1 × 10−6)

This Article

  1. Published in Advance April 24, 2009, doi: 10.1101/gr.092668.109 Genome Res. 19: 987-993

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