The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression

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Figure 1.
Figure 1.

The SMAD7 locus. (a) Single-marker association statistics (as –log10 values) as a function of genomic position (NCBI build 36.1) obtained in the GWAS (Broderick et al. 2007) covering SMAD7 and 100 kb of flanking sequence. All known genes and transcripts in the area are shown (UCSC 2006 March 2006 assembly, NCBI build 36.1). (b) Recombination rate (cM/Mb) across the region derived from HapMap project data (release 21a). (c) The interval between B and C corresponds to the 17-kb region resequenced.

This Article

  1. Published in Advance April 24, 2009, doi: 10.1101/gr.092668.109 Genome Res. 19: 987-993

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