Integrating siRNA and protein–protein interaction data to identify an expanded insulin signaling network

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Table 1.

List of the top 10 most enriched KEGG pathways for 313 screened genes, 126 siRNA hits, and 185 module genes, respectively

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Table 1.

  • aPWN, the pathway name annotated in the KEGG pathway database.

  • bPWS, the number of genes in the given pathway set.

  • cOL, the number of genes overlapping between the pathway set and the indicated gene set (screened gene set, the siRNA hits gene set, and the PEXA module gene set).

  • dNominal P-values represent the significance of the Fisher exact test statistic under the null hypothesis that the frequency of the indicated KEGG pathway gene set is the same between a reference set of 27,240 genes (genes with protein sequence data in MGI) and the genes comprising the set of screened genes, the set of siRNA hit genes, or the PEXA module.

This Article

  1. Published in Advance March 4, 2009, doi: 10.1101/gr.087890.108 Genome Res. 19: 1057-1067

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