The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host–pathogen interactions

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Table 4.

Test statistics for natural selection from human variation in the large exons of APOL5 and APOL6 from 24 African Americans

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^aThe coding sequence of each large exon was analyzed. Bolded values in the table indicate statistical significance with P < 0.05.
^bS indicates segregating sites. In each gene tested, S is also equal to the number of mutations.
^chs indicates the number of singleton mutations.
^dPi indicates the average number of nucleotide differences between pairs of sequences per site.
^eθ indicates the effective population size multiplied by the mutation rate per generation per site.

Published in Advance March 19, 2009, doi: 10.1101/gr.085647.108 Genome Res. 2009. 19: 850-858

The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host–pathogen interactions