The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host–pathogen interactions

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Table 2.

Whole-gene dN/dS comparisons reveal that APOL genes have rapidly evolved in primates of diverse ancestry

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Table 2.

  • aComparisons marked n.a. (not available) were excluded for the following reasons: The gene does not exist in the current genome assembly (chimpanzee APOL1 and APOL4, macaque APOL3, marmoset APOL1 and APOL4), the gene is a putative pseudogene (macaque APOL1 and APOL5, marmoset APOL2), or the gene is not completely sequenced in the current genome assembly (marmoset APOL5).

  • bNumbers in parentheses indicate the numbers of nonsynonymous and synonymous changes, respectively, between orthologs.

  • cThe orthology of marmoset APOL3/L4 is unclear. Since it is nearly equally related to human APOL3 and APOL4, we arbitrarily chose to compare it to APOL3.

This Article

  1. Published in Advance March 19, 2009, doi: 10.1101/gr.085647.108 Genome Res. 19: 850-858

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