Evolutionary descent of a human chromosome 6 neocentromere: A jump back to 17 million years ago

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Figure 3.
Figure 3.

Partial view of the ChIP-chip analysis data on chromosome 6, using anti-CENP-A and anti-CENP-C antibodies. Results are presented as the log2 ratio between the hybridization signal obtained with immunoprecipitated DNA using anti-CENP-A or CENP-C antibodies and that from the input DNA sample. The x-axis shows the genomic position of each oligo on chromosome 6. The data are visualized by the SignalMap software (NimbleGen Systems, Inc.). Details of the microarray structure are reported at the NimbleGen site (http://www.nimblegen.com). The CENP-A and CENP-C domains (the shaded area) clearly map at chr6:26,407–26,491 kb and chr6:26,415–26,491 kb, respectively. Below is shown the RepeatMasker analysis of the interspersed repetitive DNA elements as deducted by the UCSC Genome Browser. The “RNA” lane includes the tRNA elements.

This Article

  1. Genome Res. 19: 778-784

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