Figure 4.
KIR3DL1 and KIR3DL2 differ at 68 amino acid residues spread throughout the polypeptide. Shown are the amino acid differences that distinguish 3DL1, 3DL2, and 3DL1/2v (3DL1*059). (Gray boxes) Differences that occur in the second ITIM motif of the cytoplasmic tail. Residue numbers are those of the mature protein. The 3DL1*059 sequence that was independently obtained from cDNA (Shilling et al. 2002) is identical to the amino acid sequence encoded by the 3DL1/2v gene characterized here (Fig. 1).
