Figure 3.
Bottom-up population genomics. Genome-wide scans of positive selection are agnostic to phenotypic data and make inferences of selection directly from patterns of genetic variation (dashed black arrow). However, selection acts directly on phenotypic variation and only indirectly on DNA sequence variation (dark green arrows). Solid black arrows show that the path from genetic to phenotypic variation runs through dynamic molecular networks (such as regulatory, protein, and metabolite). Scale-free molecular networks were simulated with the R package igraph and visualized in CytoScape (Cline et al. 2007).
