Angela Taddei; Griet Van Houwe; Shigeki Nagai; Ionas Erb; Erik van Nimwegen; Susan M. Gasser

The functional importance of telomere clustering: Global changes in gene expression result from SIR factor dispersion

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Figure 3.

Esc1 and Yku70 cooperate to sequester SIR proteins at the NE. (A) Efficiency of ectopic silencing at lys2∷E-ADE2-I in GA-2511 (WT), and derivatives carrying full deletions of either yku70 (GA-2585) or yk70 esc1 (GA-2902). (B) Targeted silencing at the hmr∷e-URA3-I reporter is monitored as in Figure 1 in GA-2511 (WT), and derivatives carrying full deletions of either yku70 (GA-2585), esc1 (GA-2886), or yk70 esc1 (GA-2902).