Median-joining network of the CM-cluster haplotypes. The tree shows a potential evolutionary path for the haplotypes from Supplemental Figure 1B. Circles represent distinct haplotypes and are scaled to approximate haplotype frequencies. Bars indicate the mutational distance between the haplotypes. The mutational distance between two sequences is defined as the fraction of sites where the residues differ in the alignment of these two sequences. In the case of haplotypes, this is the number of SNP sites that harbor not the same allelic variant on both haplotypes. The ellipses in gray mark the group of protective haplotypes (defined by SNP rs2569193, rs2240695, rs17286676), whereas the ellipse in black summarizes the risk associated group of haplotypes (defined by SNP rs6879217).
