Jérôme Eeckhoute; Mathieu Lupien; Clifford A. Meyer; Michael P. Verzi; Ramesh A. Shivdasani; X. Shirley Liu; Myles Brown

Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers

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Figure 4.

FOXA1 binding sites with high FAIRE-chip signals correlate with gene expression in breast cancer. Distribution of FOXA1 binding sites with different FAIRE enrichments relative (within 20 kb of the TSS) to genes co-expressed or non-co-expressed with FOXA1 in primary breast tumors (van de Vijver et al. 2002; Wang et al. 2005). ** Indicates a statistically significant difference between the distribution of FOXA1 binding sites near correlated and non-correlated genes (P < 0.01).