A SILAC-based DNA protein interaction screen that identifies candidate binding proteins to functional DNA elements

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Table 2.

Proteins binding preferentially to the DNA column bearing the fully methylated CpG island of the human MTA2 gene

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Table 2.

  • PCNA interaction motifs (Warbrick 2000) are present in KIAA0101 (QKGIGEFFRL, aa 62–71) and DNMT1 (RQTTITSHFAK, aa 163–173). UHRF1 possesses ubiquitin E3 ligase activity in vitro and USP7, an ubiquitin protease, stabilizes E3 ligases by preventing their auto-ubiquitination (for details, see Supplemental Fig. S4).

  • aNumber of identified unique peptides for specific binders.

  • bNumber of quantified peptides for specific binders.

  • cBiological functions are listed, if known.

This Article

  1. Published in Advance November 17, 2008, doi: 10.1101/gr.081711.108 Genome Res. 19: 284-293

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