L1PA4 repeat insertions at the breakpoints. Human–gibbon pairwise alignment by miropeats is shown. The NLE gibbon-specific segmental duplications are also remarkable. LINE-1 elements, L1PA4 (green block arrows), and L1MA3 (dark green arrows) in the vicinity of human–gibbon synteny breaks are shown. There are three L1PA4 elements (underlined) in panel A and one in panel B. Note that the L1PA4 elements are specific to the NLE gibbon chromosomal segment. (Black dotted lines) Extent of breakpoint intervals and sequence structure of each repeat. The directions of the arrows denote orientation of the LINEs, and the numbers denote the sequence extent.
