A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 3.
Figure 3.

(A) Four clusters of breakpoints at 1p13.1-21.1, 3p14.1-p14.2, 17q22-q24.3, and 20q12-q13.33. (B) Low copy repeat (LCR) association with clustered and dispersed breakpoints. (C) The four clusters of breakpoints correspond exactly to the four highly amplified regions in MCF-7, as determined by array CGH.

This Article

  1. Published in Advance December 3, 2008, doi: 10.1101/gr.080259.108 Genome Res. 19: 167-177

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research