Comparative analysis of human and chimpanzee centromere sequences. (A) JDotter alignment of human chromosome X HOR unit (DXZ1; accession X02418) plotted against the chimpanzee orthologous sequence (accession no. X66287). HOR units exhibit a high degree of sequence homology and maintain sequence colinearity across their 2.0-kb lengths. (B) Human chromosome 17 HOR unit (D17Z1; accession no. M13882) plotted against an available segment of chimpanzee orthologous sequence (PTR219; accession no. F L08574) exhibits substantial sequence homology and conservation of sequence colinearity. (C) Increased sequence divergence and an absence of sequence colinearity is exhibited when the human Y-centromere HOR (DYZ3; accession no. AF522078Y) is plotted against the chimpanzee orthologous sequence (Repbase ALRY-MAJOR_PT). JDotter plots were created using a 50-bp sliding window with grayscale set at identical parameters.
