Distinguishing direct versus indirect transcription factor–DNA interactions

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Figure 2.
Figure 2.

High-scoring motifs in the Cbf1_YPD ChIP-chip data set. (A) AUC values for the 139 PBM-derived motifs in the Cbf1_YPD data set. The x-axis shows the TF ranks, computed as in Figure 1C. (B) The three motifs that exhibit high AUC values in this data set: Tye7, Cbf1, and Rtg3. (C) Venn diagram showing the overlap among the sets of probes bound by Tye7, Cbf1, and Rtg3 in rich medium (YPD). Given the high similarity among the three motifs and the small overlap among the probes bound by the three factors, we do not consider this a case of indirect DNA binding by Cbf1.

This Article

  1. Genome Res. 19: 2090-2100

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